Experiment 8 Acetylsalicylic Acid Experiment - 1650 Words

Monica Perez Experiment 8: Acetylsalicylic Acid Experiment 01/25/2013 CHM Lab- 2211 Sec 0016 Instructor: Jennifer Reed Introduction: Commonly used as Aspirin, acetylsalicylic acid is an analgesic (pain reliever), which is one of the products of the esterification reaction between salicylic acid and acetic anhydride. This esterification occurs since the hydroxyl group from the salicylic acid reacts with acetic anhydride to form an ester. In this experiment, we will be able to recreate this acid catalyzed reaction, using sulfuric acid as our catalyst in order to produce acetylsalicylic acid and acetic acid. The final product of this reaction will be some crystals, which will be mainly composed of acetylsalicylic acid. In order†¦show more content†¦Test the filtration device with water, before placing the crystals in the solution. Filter the crystalinization product for 5-10 min and finally rinse the crystals with some distilled water. Re-crystallization of Crude Acetylsalicylic Acid Dissolve crude product of previous crystalinization in a clean 125 mL Erlenmeyer flask with ethyl acetate (2-3 mL). Gently heat the solution on a hot plate to dissolve the reagents and then allow the solution to cool down at room temperature. At this point crystals should form, if not add petroleum ether to the solution. Place the flask with the solution on an ice bath until crystallization is complete. Once again, set up the vacuum filtration that was used to collect crude crystal product and vacuum dry the crystals for 10 minutes. Perform the ferric chloride test by setting up four test tubes with salicylic acid, products of crystalinization, products of re-crystalinization and distilled water respectively in order to detect the presence of phenol. Finally, after placing the products of re-crystalinization in the oven for 5-10 min record its mass and its melting point. Conclusion: Our results lead us to think that the possible reason for this low percentage, as well as for the differences between melting point range obtained and the actual melting point (128- 130  ° C 0  ° C instead of 135- 136  ° C) might have been due errors in the time that the re-crystallized sample spent in the oven. This theory is reinforced byShow MoreRelatedExperiment 2a Adsorption Chromatography ( Tlc )1455 Words   |  6 PagesNAME: ____Amy Hua_______________________ Experiment 4a Adsorption Chromatography (TLC) Summary of Points for Experiment 4a: Item Possible Points Actual Points Pre-Lab 2 Notebook: N/A N/A Purpose/Table of Reagents 2 Corrections 2 Blank Spaces 2 Signatures 2 TLC data (4-in notebook) 8 Coherent 2 Conclusions (absent here) 1 Sub-Total = 21 multiply Sub-Total x 2= 42 Report: N/A N/A Introduction 2 Data and Calculations 8 Less Points-Missing Data N/A N/A Unknown Identity 10 Read MoreLab Report On Aspirin1180 Words   |  5 PagesThe purpose of this lab experiment is to study a simple esterification reaction, producing acetylsalicylic acid (aspirin), thus becoming familiar with synthetic chemistry tools and techniques. Introduction1 Organic molecules can be classified based on the functional groups that they possess. One of these classes is esters, which are produced from an acid and an alcohol as shown in the following figure. Figure 1: Reaction of a carboxylic acid and an alcohol to form and ester.2 Based on theRead MoreSynthesis and Characterization of Aspirin Product Identity and Purity After synthesizing a1000 Words   |  4 Pagesdetect the presence of leftover salicylic acid in the synthesized aspirin and allow you to determine its concentration. Government regulations stipulate that commercial aspirin must not contain residual salicylic acid since it is irritating to the mouth, throat, and stomach. Iron salts react with phenols to form a complex ion that has a purple color, therefore iron (III) chloride can be used to determine if your aspirin sample contains residual salicylic acid. The second test uses melting point toRead MoreIsolation of the Active Ingredient in an Analgesic Drug1344 Words   |  6 PagesSasha Thiel 09.10.2012 CH203 Lab Experiment 1: Isolation of the Active Ingredient in an Analgesic Drug Pre-Lab: A. Least accurate to most accurate 1. Beakers (5ml markings) 2. 10ml graduated cylinder (0.1 markings) 3. 5ml vials (0.1 and 0.3 markings) 4. 1ml plastic pipets (0.1 ml markings) 5. 1ml syringes (0.1 ml markings) 6. 1ml graduated volumetric pipets (0.01 ml markings) B. A 1ml graduated volumetric pipet is the best to use if you want 0.15 ml of reactant Read MoreAnalysis of Aspirin1901 Words   |  8 Pages1. Aim To determine the percentage of aspirin in different commercial preparations and to find which is the best value for money 2. Hypothesis The greater the percentage of acetylsalicylic acid (ASA) in the tablet, more powerful and efficient the aspirin would be due to the way aspirin works in human’s body. Aspirin is often used to alleviate the pain, and the sensation of pain is mainly attributed to a chemical substance called prostaglandins, which is responsible to send a strong signalRead MoreEssay on Synthesis of Aspirin5275 Words   |  22 Pagesyield and test the purity of aspirin by adding Iron (III) chloride to the product. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid (aspirin) and acetic acid (vinegar). Variables: Independent and controlled variables: The amount of sulfuric acid used for catalysis and the amount of salicylic acid and acetic anhydride. Dependent variables: Theoretical and actual yield of aspirin. Constant variables: Two beakers filled withRead MoreA Short Note On Aspirin And The Chemical Substance1287 Words   |  6 Pages all of the labs consisted of the analysis of Aspirin. Even though Aspirin is the most common drug used worldwide, it has been known to smell like vinegar. This is because aspirin is considered a salicylate. The formula name for Aspirin is Acetylsalicylic Acid, and the chemical equation is C9H8O4. The background behind Aspirin is that it aids in pain relief and reducing inflammation, swelling, and fever. Also, some benefits of aspirin are that it can treat skin problems such as acne, warts, and psoriasisRead MoreProject: Preparation and Recrystallisation of Aspirin2916 Words   |  12 Pages Page List of illustration iii Synopsis iv 1. Objective of experiment 1 2. Introduction 2.1Definition of aspirin Read MoreSynthesis of Salicylic Acid and Potentiometric Determination of Its Purity and Dissociation Constant4209 Words   |  17 PagesSynthesis of Salicylic Acid and Potentiometric Determination of its Purity and Dissociation Constant ------------------------------------------------- Abstract The purpose of the study is to synthesize salicylic acid from the ester, methyl salicylate, and determine the acid’s dissociation constant and purity. The ester was converted to salicylic acid by base hydrolysis. The products were refluxed and recrystallized, to ensure maximum purity, and filtered, dried, and weighed. The melting pointRead MoreThe History, Use, and Effectiveness of Medicinal Drugs4647 Words   |  19 Pagesclassified as illegal such as the drugs of marijuana and opium which were key in the Chinese, and Native American medical system. The origin of drugs vary from common plants, (Aspirin, Digitalis, Ergot, Opium, Quinine, Reserpine) to minerals, (Boric Acid, Epsom Salts, Iodine) or synthetic compounds. The difference in a drug from being helpful to being deadly is all in the dosage, which is determined by the amount of the drug that is found in the blood, this process is known as Serum Monitoring. The